Roflumilast: Quick Guide to Uses, Dosage & Safety

If you’ve been prescribed roflumilast, you probably wonder what it does and how to take it safely. This short guide breaks down the basics so you can feel confident about your treatment.

How Roflumilast Works

Roflumilast is a pill that belongs to a class called phosphodiesterase‑4 inhibitors. It reduces inflammation in the lungs, which helps people with chronic obstructive pulmonary disease (COPD) breathe easier. By lowering inflammation, the drug can cut down the number of flare‑ups you experience.

Practical Tips for Taking Roflumilast

The standard dose is 500 µg taken once a day, usually with food to avoid stomach upset. Keep the tablet whole; don’t crush or split it. If you miss a dose, take it as soon as you remember, but skip it if it’s almost time for the next one.

Common side effects include mild nausea, weight loss, and occasional diarrhea. Most people notice these symptoms in the first few weeks, and they often improve as your body adjusts. If you feel severe nausea, persistent vomiting, or an unusual rash, contact your doctor right away.

Roflumilast can affect liver enzymes, so doctors usually order a blood test before starting treatment and again after a few months. Tell your doctor if you have any liver problems, and avoid the drug if you’re pregnant or planning to become pregnant.

Alcohol can make side effects worse, especially stomach issues. Try to limit drinking while on roflumilast. Also, let your pharmacist know about any other medicines you take—antibiotics, antifungals, and certain heart drugs can interact with roflumilast.

Because the medication works slowly, don’t expect instant relief. It may take several weeks to see a real drop in flare‑ups. Patience and regular use are key.

Storing roflumilast is simple: keep the bottle in a cool, dry place away from direct sunlight. Keep it out of reach of children.

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